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Previous experience with comparable sequences can make us vulnerable

Dimethyl fumarate (DMF), an FDA-approved drug prescribed for the treatment of multiple sclerosis (55, 56), activates NRF2 by disrupting its interaction with KEAP1 ( Figure 7A ), allowing NRF2 to translocate to the nucleus and become transcriptionally active (5557)

Moreover, staying hydrated is crucial, as water plays a vital role in the body's detoxification processes, further supporting glutathiones role in maintaining cellular health

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The most significant and intriguing finding though, is that both genes are regulated via a redox mechanism involving Nrf2-EpRE pathway

doi:0006-291X(78)91562-0 [pii]